沈冲 教授

教授，博士研究生导师。主要研究方向为心血管与代谢病流行病学、精神疾病流行病学。南京医科大学附属老年医院/江苏省老年医学研究所临床流行病研究室主任。现任中华预防医学会心脏病预防与控制专业委员会委员、中华预防医学会慢性病预防与控制分会委员、中国营养学会营养与慢病控制分会常务委员、江苏省卒中学会卒中预防与控制专业委员会副主任委员、江苏省预防医学会流行病学专业委员会委员、江苏省预防医学会慢性病预防与控制专业委员会常委、江苏省预防医学会心功能专委会常委、江苏省预防医学会糖尿病预防与控制专委会副主委、江苏省健康管理学会理事、南京医科大学脑卒中专病联盟委员；《慢性病与转化医学》（英文版）、《中华预防医学杂志》、《中华疾病控制杂志》、《实用老年医学杂志》编委。参编《医学研究的数据管理与分析》、《医学科研方法学》、《流行病学》（案例版）、《皮肤病流行病学》等10余部教材和专著的编写。主持国家自然科学基金课题面上项目4项，科技部重点研发项目子课题2项。发表论文200余篇，其中第一/通讯作者SCI收录论文50余篇。

教育经历：

1.2005-09 至2008-07，北京协和医学院，博士

2.1998-09 至2001-07，安徽医科大学，硕士

科研与学术工作经历：

2019-06 至今，南京医科大学，必一·运动(B-sports)官方网站流行病学系，教授

2011-11 至 2012-06，美国范德堡大学，流行病学研究中心，访问学者    

2011-09 至 2019-06，南京医科大学，必一·运动(B-sports)官方网站流行病学系，副教授

2009-09 至 2009-12，瑞典卡罗林斯卡医学院，糖尿病研究中心，访问学者

主要在研项目：

1、科技部重点研发计划专项、中国中部地区主动健康云平台示范应用与评价（2018YFC2000703-1）、2018/12/21-2021/12/31、92万、主持。

2、国家自然科学基金面上项目、KLFs信号通路遗传变异与高血压和脑卒中关系的分子流行病学研究（81872686）、2019/01-2022/12、57万元、在研、主持。

3、国家自然科学基金面上项目、缺血性脑卒中外周血差异表达mRNA筛选、验证及基因-环境交互作用研究（82173611）、2022/01-2025/12、52万元、在研、主持。

近几年主要论文：

1. Chen C, Gu X, Liu F, Sun C, Mu J, Jin D, Sui X, Geng D, Li Q, Jiang Y, Shen C. SNP rs3803264 polymorphisms in THSD1 and abnormally expressed mRNA are associated with hemorrhagic stroke. Front Aging Neurosci. 2023 Apr 17;15:1144364. 

2. Bafei SEC, Zhao X, Chen C, Sun J, Zhuang Q, Lu X, Chen Y, Gu X, Liu F, Mu J, Wei L, Wei P, Yin Y, Xie H, Yang S, Shen C. Interactive effect of increased high sensitive C-reactive protein and dyslipidemia on cardiovascular diseases: a 12-year prospective cohort study. Lipids Health Dis. 2023 Jul 4;22(1):95.

3. Chen C, Chen X, Yang S, Li Q, Ren Z, Wang L, Jiang Y, Gu X, Liu F, Mu J, Liu L, Wang Y, Li J, Yu Y, Zhang J, Shen C. Association of THBS1 genetic variants and mRNA expression with the risks of ischemic stroke and long-term death after stroke. Front Aging Neurosci. 2022 Sep 23;14:1006473.

4. Xie H, Zhuang Q, Mu J, Sun J, Wei P, Zhao X, Chen Y, Dong J, Chen C, Wei L, Yin Y, Yang S, Shen C. The relationship between lipid risk score and new-onset hypertension in a prospective cohort study. Front Endocrinol (Lausanne). 2022 Sep 28;13:916951.

5. Fan Y, Gao J, Li Y, Chen X, Zhang T, You W, Xue Y,Shen C. The Variants at APOA1 and APOA4 Contribute to the Susceptibility of Schizophrenia With Inhibiting mRNA Expression in Peripheral Blood Leukocytes. Front Mol Biosci. 2021. doi: 10.3389/fmolb.2021.785445.

6. Dong J, Yang S, Zhuang Q, Sun J, Wei P, Zhao X, Chen Y, Chen X, Li M, Wei L, Chen C, Fan Y,Shen C. The Associations of Lipid Profiles With Cardiovascular Diseases and Death in a 10-Year Prospective Cohort Study. Front Cardiovasc Med. 2021. doi: 10.3389/fcvm.2021.745539.

7. Cheng Y, Liu M, Liu Y, Xu H, Chen X, Zheng H, Wu X, Shen Z,Shen C. Chronic kidney disease: prevalence and association with handgrip strength in a cross-sectional study. BMC Nephrol. 2021;22(1):246. doi: 10.1186/s12882-021-02452-5.

8. Liu C, Yin Q, Li M, Fan Y,Shen C, Yang R. ACTB Methylation in Blood as a Potential Marker for the Pre-clinical Detection of Stroke: A Prospective Nested Case-Control Study. Front Neurosci. 2021;15:644943. doi: 10.3389/fnins.2021.644943.

9. Tian Y, Tang W, Yang S, Zhao Y, Chen Y, Zhao X, Liu C, Chen X,Shen C. HTRA1 Variants and the Interaction with Smoking Confer the Genetic Susceptibility to Ischemic Stroke. Int J Med Sci. 2021;18(8):1840-1847. doi: 10.7150/ijms.45856.

10. Liu C, Tang W, Zhao H, Yang S, Ren Z, Li J, Chen Y, Zhao X, Xu D, Zhao Y,Shen C. The variants at FLNA and FLNB contribute to the susceptibility of hypertension and stroke with differentially expressed mRNA. Pharmacogenomics J. 2021;21(4):458-466. doi: 10.1038/s41397-021-00222-y.

11. Yao Yingshui, Hui Zhu, Lijun Zhu, Zhengmei Fang, Yao Fan, Chunlan Liu, Yuanrui Tian, Yan Chen, Wuzhuang Tang, Zhanyun Ren, Jie Li, Song Yang, Yanchun Chen, Xianghai Zhao, andChong Shen, A comprehensive contribution of genetic variations of the insulin-like growth factor 1 signalling pathway to stroke susceptibility.Atherosclerosis, 2020. 296: p. 59-65.

12. Yang, Song, Yanping Zhao, Xiaotian Chen, Xiangfeng Lu, Yanchun Chen, Xianghai Zhao, Lijun Zhu, Zhengmei Fang, Hailong Zhao, Yingshui Yao, Chunlan Liu, andChong Shen, The ACTB Variants and Alcohol Drinking Confer Joint Effect of Ischemic Stroke in Chinese Han Population.Journal of Atherosclerosis and Thrombosis, 2020. 27(3): p. 226-244.

13. Ren, Zhanyun, Xiaotian Chen, Wuzhuang Tang, Jie Li, Song Yang, Yanchun Chen, Xianghai Zhao, Huihua Zong, Chunlan Liu, andChong Shen, Association of DIAPH1 gene polymorphisms with ischemic stroke.Aging-Us, 2020. 12(1): p. 416-435.

14. Yang, Song, Mengxia Li, Yanchun Chen, Xianghai Zhao, Xiaotian Chen, Hui Wang, Yuanrui Tian, Chunlan Liu, andChong Shen, Comparison of the Correlates Between Body Mass Index, Waist Circumference, Waist-to-Height Ratio, and Chronic Kidney Disease in a Rural Chinese Adult Population.Journal of Renal Nutrition, 2019. 29(4): p. 302-+.

15. Yang, Song, Xiaotian Chen, Mengyao Yang, Xianghai Zhao, Yanchun Chen, Hailong Zhao, Chunlan Liu, andChong Shen, The variant at TGFBRAP1 is significantly associated with type 2 diabetes mellitus and affects diabetes-related miRNA expression.Journal of Cellular and Molecular Medicine, 2019. 23(1): p. 83-92.

16. Wang, Laiyuan,Chong Shen, Yanyu Wang, Tianyu Zou, Huijuan Zhu, Xiaomei Lu, Lin Li, Bin Yang, Jichun Chen, Shufeng Chen, Xiangfeng Lu, and Dongfeng Gu, Identification of circular RNA Hsa_circ_0001879 and Hsa_circ_0004104 as novel biomarkers for coronary artery disease.Atherosclerosis, 2019. 286: p. 88-96.

17. ul Haq, Ijaz, Yu Liu, Min Liu, Haifeng Xu, Hui Wang, Chunlan Liu, Falak Zeb, Pan Jiang, Xiaoyue Wu, Yuanrui Tian, Mengxia Li, Qun Li, Jun Fu,Chong Shen, and Qing Feng, Association of Smoking-Related Knowledge, Attitude, and Practices (KAP) with Nutritional Status and Diet Quality: A Cross-Sectional Study in China.Biomed Research International, 2019. 2019.

18. Mallah, Manthar Ali, Min Liu, Yu Liu, Hai-Feng Xu, Xiao-Jun Wu, Xiao-Tian Chen, Hui Wang, Chun-Lan Liu, Yuan-Rui Tian, Meng-Xia Li, Qun Li, Jun Fu, andChong Shen, Association of handgrip strength with the prevalence of hypertension in a Chinese Han population.Chronic diseases and translational medicine, 2019. 5(2): p. 113-121.

19. Li, Mengxia, Ming Wu, Yu Qin, Jinyi Zhou, Jian Su, Enchun Pan, Qin Zhang, Ning Zhang, Hongyan Sheng, Jiayi Dong, Ye Tong, andChong Shen, ACTB Variants Confer the Genetic Susceptibility to Diabetic Kidney Disease in a Han Chinese Population.Frontiers in Genetics, 2019. 10.

20. Chen, Yan, Lijun Zhu, Zhengmei Fang, Yuelong Jin,Chong Shen, Yingshui Yao, and Chengchao Zhou, Soluble guanylate cyclase contribute genetic susceptibility to essential hypertension in the Han Chinese population.Annals of Translational Medicine, 2019. 7(22).